Hydrolysis in Drug and Prodrug Metabolism, Leki
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Hydrolysis
in Drug and Prodrug Metabolism
Chemistry, Biochemistry, and Enzymology
Hydrolysis in Drug and Prodrug Metabolism.
Bernard Testa, Joachim M. Mayer
© Verlag Helvetica Chimica Acta, Postfach, CH8042 Zürich, Switzerlaand, 2003
Hydrolysis
in Drug and Prodrug Metabolism
Chemistry, Biochemistry, and Enzymology
Bernard Testa, Joachim M. Mayer
Verlag Helvetica Chimica Acta
Prof. Bernard Testa
Institute of Medicinal Chemistry
School of Pharmacy
University of Lausanne
CH-1015 Lausanne
Switzerland
This book was carefully produced. Nevertheless, authors and publishers do not warrant the information contained therein
to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details, or other
items may inadvertently be inaccurate.
Published jointly by
VHCA, Verlag Helvetica Chimica Acta AG, Zürich (Switzerland)
WILEY-VCH GmbH & Co. KGaA, Weinheim (Federal Republic of Germany)
Editorial Directors: Thomas Kolitzus, Dr. Patricia L. Bounds
Production Manager: Norbert Wolz
Cover Design: Bettina Bank
Library of Congress Card No. applied for.
A CIP catalogue record for this book is available from the British Library.
Bibliographic information published by Die Deutsche Bibliothek.
Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie;
ISBN 3-906390-25-X
©
Verlag Helvetica Chimica Acta, Postfach, CH–8042 Zürich, Switzerland, 2003
Printed on acid-free paper.
All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form
– by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written
permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such,
are not to be considered unprotected by law.
Printing: Konrad Triltsch, Print und Digitale Medien, D-97199 Ochsenfurt-Hohestadt
Printed in Germany
Dedicated to the fond memory of
Joachim M. Mayer
(1957 – 2001),
former graduate students, colleagues, and friends in eternity
(1949 – 2001) and
Nabil El Tayar
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